Bromine → HCID 87436834、化合物
反応式
[Br:1]Br.[Cl:3][C:4]1[S:8][C:7]([C:9](=[O:17])[CH2:10][C:11]2[CH:16]=[CH:15][N:14]=[CH:13][CH:12]=2)=[CH:6][CH:5]=1>C(O)(=O)C>[Br:1][CH:10]([C:11]1[CH:16]=[CH:15][N:14]=[CH:13][CH:12]=1)[C:9]([C:7]1[S:8][C:4]([Cl:3])=[CH:5][CH:6]=1)=[O:17]参加物
4
実験手順
At room temperature, 26.9 g (167 mmol) of bromine are added dropwise to a solution of 40.0 g (167 mmol) of 1-(5-chloro-2-thienyl)-2-(pyridin-4-yl)ethanone in 200 ml of acetic acid, and the mixture is stirred for 90 min. The resulting precipitate is filtered off, washed with MTBE and dried. This gives 64.5 g (96%) of the desired product; log P (pH2.7): 2.18 with MS (ESI): 315.9 ([M+H]+).
後処理
- filtrationThe resulting precipitate is filtered off
- washwashed with MTBE
- customdried
出典と根拠
- ORDレコード
- ord-970811bb599e441fb5a062e2dc6340a2
- 出典データセット
- uspto-grants-2015_12
- 特許番号
- US09198426B2
反応ノート
読み込み中…