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Potassium Carbonate → 1-(4-(3-Ethoxy-4-nitrophenyl)piperazin-1-yl)ethanone
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Potassium Carbonate | HCID 11430 | — |
| 反応物 | 1-Acetylpiperazine | HCID 83795 | — |
| 反応物 | 2-Ethoxy-4-fluoronitrobenzene | HCID 12918153 | — |
| 溶媒 | Dimethylformamide | HCID 6228 | — |
| 生成物 | 1-(4-(3-Ethoxy-4-nitrophenyl)piperazin-1-yl)ethanone | HCID 118105754 | — |
反応手順
The compound obtained in Step 1 above (300 mg), N-acetylpiperazine (300 mg), and potassium carbonate (500 mg) were dissolved in dimethylformamide (3 mL) and reacted at 80° C. overnight. The dimethylformamide of the reaction mixture was removed under reduced pressure, and added with water to form a solid. The solid was filtered to obtain a target compound as a yellow solid.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US09199944B2 |
| 出典データセット | uspto-grants-2015_12 |
| ORD ID | ord-2c8e1a83285440b6b1edfc06111e3ca8 |
| 出典メモ | uspto-grants-2015_12 |