HCID 90383149、化合物 → 4-(4-Acetyl-piperazin-1-YL)-2-chloroaniline
反応式
[Cl:1][C:2]1[CH:3]=[C:4]([N:11]2[CH2:16][CH2:15][N:14]([C:17](=[O:19])[CH3:18])[CH2:13][CH2:12]2)[CH:5]=[CH:6][C:7]=1[N+:8]([O-])=O>C(O)C>[NH2:8][C:7]1[CH:6]=[CH:5][C:4]([N:11]2[CH2:16][CH2:15][N:14]([C:17](=[O:19])[CH3:18])[CH2:13][CH2:12]2)=[CH:3][C:2]=1[Cl:1]参加物
3
反応条件
- 温度
- 90 °C
実験手順
The compound prepared in Step 1 was dissolved in ethanol (10 ml) and distilled water (1.0 ml), added with iron (powder, 2.0 g) and ammonium chloride (1.0 g), and stirred at 90° C. for 2 hours. Then, the resultant was filtered using celite and the filtrate was distilled under reduced pressure to remove the solvent. The resulting white solid was used in the subsequent reaction without further purification.
後処理
- distillationdistilled water (1.0 ml)
- additionadded with iron (powder, 2.0 g) and ammonium chloride (1.0 g)
- filtrationThen, the resultant was filtered
- distillationthe filtrate was distilled under reduced pressure
- customto remove the solvent
- customThe resulting white solid was used in the subsequent reaction without further purification
出典と根拠
- ORDレコード
- ord-ba5414df8f934728aa66e9826a823895
- 出典データセット
- uspto-grants-2015_12
- 特許番号
- US09199944B2
反応ノート
読み込み中…