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Water → 4-Chloro-1-nitro-2-phenoxybenzene

HRID 1496958
ノート
印刷プレビュー

反応式

HRID 1496958 の反応式
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([N+:8]([O-:10])=[O:9])=[C:4](F)[CH:3]=1.[C:12]1([OH:18])[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=1.C(=O)([O-])[O-].[K+].[K+].O>CS(C)=O.C(OCC)C>[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([N+:8]([O-:10])=[O:9])=[C:4]([O:18][C:12]2[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=2)[CH:3]=1
参加物実験手順後処理出典と根拠反応ノート

参加物

7

反応物 4

HCID 962WaterHCID 996PhenolHCID 11430Potassium CarbonateHCID 696914-Chloro-2-fluoro-1-nitrobenzene

生成物 1

HCID 122900444-Chloro-1-nitro-2-phenoxybenzene

試薬・触媒・溶媒 2

HCID 679Dimethyl Sulfoxide溶媒
HCID 3283
Diethyl Ether
溶媒

実験手順

4-chloro-2-fluoro-nitrobenzene (500 mg), phenol (270 mg), and potassium carbonate (400 mg) were dissolved in dimethyl sulfoxide (10 ml), and stirred at room temperature for 2 hours. The mixture was added with water and ethyl ether to extract an organic layer. The resulting organic layer was washed with saturated brine, and water was removed with sodium sulfate, and the solvent was removed by distillation under reduced pressure. The yellow target compound obtained by removing the solvent was used in the subsequent reaction without further purification (500 mg).

後処理

  1. extractionto extract an organic layer
  2. washThe resulting organic layer was washed with saturated brine, and water
  3. customwas removed with sodium sulfate
  4. customthe solvent was removed by distillation under reduced pressure
  5. customThe yellow target compound obtained
  6. customby removing the solvent
  7. customwas used in the subsequent reaction without further purification (500 mg)

出典と根拠

ORDレコード
ord-0ab8e1930a96477aa8d4a839d683cd10
出典データセット
uspto-grants-2015_12
DOI
10.6084/m9.figshare.5104873.v1
特許番号
US09199944B2

反応ノート

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