Methyl malonyl chloride → HCID 86682941、化合物

HRID 1497074ノート

反応式

HRID 1497074 の反応式
Cl[C:2](=[O:8])[CH2:3][C:4]([O:6][CH3:7])=[O:5].[NH2:9][C:10]1[C:15]([Cl:16])=[CH:14][C:13]([Cl:17])=[CH:12][C:11]=1[C:18]([C:20]1[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=1)=[O:19]>C(Cl)Cl>[CH3:7][O:6][C:4](=[O:5])[CH2:3][C:2]([NH:9][C:10]1[C:15]([Cl:16])=[CH:14][C:13]([Cl:17])=[CH:12][C:11]=1[C:18](=[O:19])[C:20]1[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=1)=[O:8]

参加物

4

反応物 2

HCID 123460Methyl malonyl chlorideHCID 12516780(2-Amino-3,5-dichlorophenyl)(phenyl)methanone

生成物 1

HCID 86682941HCID 86682941、化合物

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒

実験手順

Methyl 3-chloro-3-oxopropanoate (317 mg, 249 μl, 2.25 mmol, Eq: 1.2) was added dropwise to a yellow solution of (2-amino-3,5-dichloro-phenyl)-phenyl-methanone (500 mg, 1.88 mmol, Eq: 1.00) in DCM (5 ml) at 0° C. The yellow solution was then allowed to warm slowly to RT. After completion of the reaction the mixture was washed with sat. NaHCO3 solution and brine, dried with Na2SO4 and evaporated. The remaining light brown residue (603 mg) was used in the next reaction step without further purification. MS (ESI): 366.0 (M+H)+.

後処理

  1. customAfter completion of the reaction the mixture
  2. washwas washed with sat. NaHCO3 solution and brine
  3. dry with materialdried with Na2SO4
  4. customevaporated
  5. customThe remaining light brown residue (603 mg) was used in the next reaction step without further purification

出典と根拠

ORDレコード
ord-998d4d5658704a9da0232698b0de309b
出典データセット
uspto-grants-2015_12
特許番号
US09199938B2

反応ノート

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