化工社化工社 化学情報印刷レポート · 研究参考用
Triethylamine → (1-Benzyl-1H-indazol-5-yl)-(6-bromoquinazolin-4-yl)amine
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Triethylamine | HCID 8471 | — |
| 反応物 | 1-(Phenylmethyl)-1H-indazol-5-amine | HCID 212069 | — |
| 反応物 | 6-Bromo-4-chloro-quinazoline | HCID 16770310 | — |
| 溶媒 | Water | HCID 962 | — |
| 溶媒 | Acetonitrile | HCID 6342 | — |
| 溶媒 | Ethyl Acetate | HCID 8857 | — |
| 生成物 | (1-Benzyl-1H-indazol-5-yl)-(6-bromoquinazolin-4-yl)amine | HCID 21951963 | 83.4% |
反応手順
Prepared according to Procedure A from 6-bromo-4-chloroquinazoline (5.0 g) and 5-amino-1-benzyl-1H-indazole (5.0 g) in acetonitrile (100 ml) at 100° C. The resulting precipitate was treated with triethylamine in ethyl acetate and water to give the title compound as a yellow solid, (7.37 g); δH [2H6]-DMSO 9.93 (1H, s), 8.82 (1H, d), 8.52 (1H, s), 8.19 (1H, s), 8.09 (1H, s), 7.92 (1H, dd), 7.65 (3H, m), 7.25 (5H, m), 5.62 (2H, s).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US09199973B2 |
| 出典データセット | uspto-grants-2015_12 |
| ORD ID | ord-935f8a60fee2416b81f044c9893df114 |
| 出典メモ | uspto-grants-2015_12 |