Labuxtinib → HCID 71280845、化合物
反応式
[F:1][C:2]1([F:29])[CH2:4][C@@H:3]1[C:5]1[O:9][N:8]=[C:7]([C:10]2[CH:11]=[CH:12][C:13]([CH3:28])=[C:14]([NH:16][C:17]([C:19]3[N:23]4[CH:24]=[CH:25][CH:26]=[CH:27][C:22]4=[N:21][CH:20]=3)=[O:18])[CH:15]=2)[N:6]=1.F[C:31]1(F)C[C@H]1C1ON=C(C2C=CC(C)=C(NC(C3N4C=CC=CC4=NC=3)=O)C=2)N=1.F[C@@H]1C[C@H]1C1ON=C(C2C=CC(C)=C(NC(C3N4C=CC=CC4=NC=3)=O)C=2)N=1.F[C@H]1C[C@@H]1C1ON=C(C2C=CC(C)=C(NC(C3N4C=CC=CC4=NC=3)=O)C=2)N=1>>[F:1][C:2]1([F:29])[CH2:4][CH:3]([C:5]2[O:9][N:8]=[C:7]([C:10]3[CH:11]=[CH:12][C:13]([CH3:28])=[C:14]([NH:16][C:17]([C:19]4[N:23]5[CH:24]=[CH:25][CH:26]=[CH:27][C:22]5=[N:21][CH:20]=4)=[O:18])[CH:15]=3)[N:6]=2)[CH2:31]1参加物
5
実験手順
N-(5-{5-[(1R)-2,2-difluorocyclopropyl]-1,2,4-oxadiazol-3-yl}-2-methylphenyl)imidazo[1,2-a]pyridine-3-carboxamide; N-(5-{5-[(1S)-2,2-difluorocyclopropyl]-1,2,4-oxadiazol-3-yl}-2-methylphenyl)imidazo[1,2-a]pyridine-3-carboxamide; N-(5-{5-[(1S,2R)-2-fluorocyclopropyl]-1,2,4-oxadiazol-3-yl}-2-methylphenyl)imidazo[1,2-a]pyridine-3-carboxamide, and N-(5-{5-[(1R,2S)-2-fluorocyclopropyl]-1,2,4-oxadiazol-3-yl}-2-methylphenyl)imidazo[1,2-a]pyridine-3-carboxamide.