2,4-Dichloropyrimidine → 5-(2-Chloro-pyrimidin-4-yl)-2-fluoro-benzaldehyde

反応式

[Cl:1][C:2]1[N:7]=[C:6](Cl)[CH:5]=[CH:4][N:3]=1.[F:9][C:10]1[CH:15]=[CH:14][C:13](B(O)O)=[CH:12][C:11]=1[CH:19]=[O:20]>>[Cl:1][C:2]1[N:7]=[C:6]([C:13]2[CH:14]=[CH:15][C:10]([F:9])=[C:11]([CH:12]=2)[CH:19]=[O:20])[CH:5]=[CH:4][N:3]=1

参加物

反応物 2

HCID 775312,4-Dichloropyrimidine

HCID 2778651(4-Fluoro-3-formylphenyl)boronic acid

生成物 1

HCID 249019815-(2-Chloro-pyrimidin-4-yl)-2-fluoro-benzaldehyde収率 40%

実験手順

2,4 dichloropyrimidine and 4-fluoro-3-formylphenylboronic acid was coupled following procedure A. The yield was 40%. LC-MS showed the product was >95% pure and had the expected M+H+ of 237.

出典と根拠

ORDレコード: ord-d4bfd07c48a945799be086e5695c723b
出典データセット: uspto-grants-2010_06
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US07732444B2

反応ノート

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