Dimethylformamide dimethyl acetal → 10-Chloro-N-((dimethylamino)methylene)-5,6-dihydroimidazo[1,2-d]pyrido[4,3-f][1,4]oxazepine-2-carboxamide

HRID 1498081ノート

反応式

HRID 1498081 の反応式
[Cl:1][C:2]1[N:12]=[CH:11][C:10]2[O:9][CH2:8][CH2:7][N:6]3[CH:13]=[C:14]([C:16]([NH2:18])=[O:17])[N:15]=[C:5]3[C:4]=2[CH:3]=1.CO[CH:21](OC)[N:22]([CH3:24])[CH3:23]>C1(C)C=CC=CC=1>[Cl:1][C:2]1[N:12]=[CH:11][C:10]2[O:9][CH2:8][CH2:7][N:6]3[CH:13]=[C:14]([C:16]([N:18]=[CH:21][N:22]([CH3:24])[CH3:23])=[O:17])[N:15]=[C:5]3[C:4]=2[CH:3]=1

参加物

4

反応物 2

HCID 78373Dimethylformamide dimethyl acetalHCID 5820483010-Chloro-5,6-dihydroimidazo[1,2-d]pyrido[4,3-f][1,4]oxazepine-2-carboxamide

生成物 1

HCID 5820453910-Chloro-N-((dimethylamino)methylene)-5,6-dihydroimidazo[1,2-d]pyrido[4,3-f][1,4]oxazepine-2-carboxamide

試薬・触媒・溶媒 1

HCID 1140Toluene溶媒

実験手順

A mixture of 10-chloro-5,6-dihydroimidazo[1,2-d]pyrido[4,3-f][1,4]oxazepine-2-carboxamide (1.290 g, 4.875 mmol) and 1,1-Dimethoxy-N,N-dimethylmethanamine (3.238 mL, 24.37 mmol) in 70 ml of toluene was heated under reflux for 1 hour. After cooling the product precipitated from the reaction mixture, collected, washed with ethyl ether and dried on air. Weight 0.705 g (85%). MS(ESI+): 320.1

後処理

  1. temperaturewas heated
  2. temperatureunder reflux for 1 hour
  3. temperatureAfter cooling the product
  4. customprecipitated from the reaction mixture
  5. customcollected
  6. washwashed with ethyl ether
  7. customdried on air

出典と根拠

ORDレコード
ord-ac5e3a9515fd4ee989c5d4dbbddad94a
出典データセット
uspto-grants-2015_12
特許番号
US09198918B2

反応ノート

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