Hydrochloric Acid → (4-Fluorophenyl)(2-(piperazin-1-yl)pyrimidin-5-yl)methanone

HRID 1498844ノート

反応式

HRID 1498844 の反応式
[F:1][C:2]1[CH:28]=[CH:27][C:5]([C:6]([C:8]2[CH:9]=[N:10][C:11]([N:14]3[CH2:19][CH2:18][N:17](C(OC(C)(C)C)=O)[CH2:16][CH2:15]3)=[N:12][CH:13]=2)=[O:7])=[CH:4][CH:3]=1.Cl>O1CCOCC1>[F:1][C:2]1[CH:28]=[CH:27][C:5]([C:6]([C:8]2[CH:9]=[N:10][C:11]([N:14]3[CH2:19][CH2:18][NH:17][CH2:16][CH2:15]3)=[N:12][CH:13]=2)=[O:7])=[CH:4][CH:3]=1

参加物

4

反応物 2

HCID 313Hydrochloric AcidHCID 118023371HCID 118023371、化合物

生成物 1

HCID 118022709(4-Fluorophenyl)(2-(piperazin-1-yl)pyrimidin-5-yl)methanone収率 90.4%

試薬・触媒・溶媒 1

HCID 312751,4-Dioxane溶媒2 回

実験手順

To a solution of tert-butyl 4-(5-(4-fluorobenzoyl)pyrimidin-2-yl)piperazine-1-carboxylate (8.2 g, 21.24 mmol) in dioxane (50 mL) was added HCl in dioxane (4 M, 20 mL). The reaction mixture was stirred at RT overnight. LCMS showed the reaction was completed. The mixture was concentrated to get the title compound as a light yellow solid (5.5 g, 90%). MS (ES+) C15H15FN4O requires: 286. found: 287 [M+H]+.

後処理

  1. concentrationThe mixture was concentrated

出典と根拠

ORDレコード
ord-b35c0e9897dc4767b5efa24714bbb4cb
出典データセット
uspto-grants-2015_12
特許番号
US09200002B2

反応ノート

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