Hydrazine hydrate (1:1) → HCID 68642532、化合物

HRID 1498933

反応式

HRID 1498933 の反応式
[Cl:1][C:2]1[CH:7]=[C:6]([Cl:8])[CH:5]=[CH:4][C:3]=1[C:9]1[S:10][C:11]([C:15]([O:17]CC)=O)=[C:12]([CH3:14])[N:13]=1.O.[NH2:21][NH2:22]>C(O)C>[Cl:1][C:2]1[CH:7]=[C:6]([Cl:8])[CH:5]=[CH:4][C:3]=1[C:9]1[S:10][C:11]([C:15]([NH:21][NH2:22])=[O:17])=[C:12]([CH3:14])[N:13]=1

参加物

4

反応物 2

HCID 24654Hydrazine hydrate (1:1)HCID 58657933Ethyl 2-(2,4-dichlorophenyl)-4-methyl-1,3-thiazole-5-carboxylate

生成物 1

HCID 68642532HCID 68642532、化合物収率 88.3%

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒

実験手順

Ethyl 2-(2,4-dichlorophenyl)-4-methylthiazole-5-carboxylate (250 mg) prepared in the Step 23-1-1 was dissolved in ethanol (10 ml), and hydrazine monohydrate (794 mg) was added thereto. The mixture was heated under reflux for 23 hours. After the mixture was allowed to cool, the precipitated crystal was separated by filtration, washed with water, and dried to give 2-(2,4-dichlorophenyl)-4-methylthiazole-5-carboxylic acid hydrazide (211 mg, 88%).

後処理

  1. temperatureThe mixture was heated
  2. temperatureunder reflux for 23 hours
  3. temperatureto cool
  4. customthe precipitated crystal was separated by filtration
  5. washwashed with water
  6. customdried

出典と根拠

ORDレコード
ord-8094eb14aecd4fe688b54e3ac0a66359
出典データセット
uspto-grants-2015_12
特許番号
US09200008B2

関連ノート

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