1-(4-Bromo-2-methylphenyl)-2,2,2-trifluoroethan-1-one → (1R)-1-(4-bromo-2-methylphenyl)-2,2,2-trifluoroethan-1-ol
反応式
[Br:1][C:2]1[CH:7]=[CH:6][C:5]([C:8](=[O:13])[C:9]([F:12])([F:11])[F:10])=[C:4]([CH3:14])[CH:3]=1.BrC1C=CC([C@@H](O)C(F)(F)F)=C(N2C=CC(C)=N2)C=1>[Ir]>[Br:1][C:2]1[CH:7]=[CH:6][C:5]([C@@H:8]([OH:13])[C:9]([F:11])([F:12])[F:10])=[C:4]([CH3:14])[CH:3]=1参加物
4
実験手順
Chiral reduction of 1-(4-bromo-2-methylphenyl)-2,2,2-trifluoroethanone using the Iridium complex-catalyzed hydrogenation as described for Intermediate 1, (R)-1-(4-bromo-2-(3-methyl-1H-pyrazol-1-yl)phenyl)-2,2,2-trifluoroethanol provides (R)-1-(4-bromo-2-methylphenyl)-2,2,2-trifluoroethanol.
出典と根拠
- ORDレコード
- ord-143b9adb11884ca385a9a3a6cc1c635d
- 出典データセット
- uspto-grants-2015_12
- 特許番号
- US09199994B2
反応ノート
読み込み中…