化工社化工社 化学情報印刷レポート · 研究参考用
5-Methoxy[1,3]thiazolo[5,4-b]pyridin-2-amine → N-(5-methoxythiazolo[5,4-b]pyridin-2-yl)-2-(10-methyl-5,5-dioxo-5,10-dihydrophenothiazin-2-yl)-3-((R)-3-oxocyclopentyl)propionamide
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 5-Methoxy[1,3]thiazolo[5,4-b]pyridin-2-amine | HCID 2801557 | — |
| 反応物 | methyl (1S)-3-oxocyclopentane-1-carboxylate | HCID 13827616 | — |
| 反応物 | Ethyl (10-methyl-5,5-dioxo-5,10-dihydrophenothiazin-2-yl)acetate | HCID 59340971 | — |
| 反応物 | (S)-7-iodomethyl-1,4-d ioxaspiro[4.4]nonane | HCID 67237087 | — |
| 生成物 | N-(5-methoxythiazolo[5,4-b]pyridin-2-yl)-2-(10-methyl-5,5-dioxo-5,10-dihydrophenothiazin-2-yl)-3-((R)-3-oxocyclopentyl)propionamide | HCID 86637550 | — |
反応手順
Analogously to Example 1 and Example 36, ethyl (10-methyl-5,5-dioxo-5,10-dihydrophenothiazin-2-yl)acetate, (S)-7-iodomethyl-1,4-d ioxaspiro[4.4]nonane (prepared analogously to Example 40 from commercially available methyl (S)-3-oxo-cyclopentanecarboxylate) and 5-methoxy-thiazolo[5,4-b]pyridin-2-ylamine give N-(5-methoxythiazolo[5,4-b]pyridin-2-yl)-2-(10-methyl-5,5-dioxo-5,10-dihydrophenothiazin-2-yl)-3-((R)-3-oxocyclopentyl)propionamide.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07732440B2 |
| 出典データセット | uspto-grants-2010_06 |
| ORD ID | ord-21acdf692c1a49009e3af8ed3e8a6972 |
| 出典メモ | uspto-grants-2010_06 |