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Iodide Ion → 3-(4,4-difluorocyclohexyl)-2-(5,5-dioxo-5,10-dihydrophenothiazin-2-yl)-N-(5-methoxythiazolo[5,4-b]pyridin-2-yl)propionamide
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Iodide Ion | HCID 30165 | — |
| 反応物 | Ethyl-4,4-difluorocyclohexane carboxylate | HCID 2779138 | — |
| 反応物 | 5-Methoxy[1,3]thiazolo[5,4-b]pyridin-2-amine | HCID 2801557 | — |
| 反応物 | tert-butyl 2-ethoxycarbonylmethyl-5,5-dioxo-5H-phenothiazine-10-carboxylate | HCID 59340981 | — |
| 反応物 | 1,1-Difluoro-4-(iodomethyl)cyclohexane | HCID 67236985 | — |
| 生成物 | 3-(4,4-difluorocyclohexyl)-2-(5,5-dioxo-5,10-dihydrophenothiazin-2-yl)-N-(5-methoxythiazolo[5,4-b]pyridin-2-yl)propionamide | HCID 58024254 | — |
反応手順
Analogously to Example 36 and Example 44, tert-butyl 2-ethoxycarbonylmethyl-5,5-dioxo-5H-phenothiazine-10-carboxylate, 1,1-difluoro-4-iodomethylcyclohexane (prepared from commercially available ethyl 4,4-difluorocyclohexanecarboxylate analogously to the synthesis of the iodide described in Example 40) and 5-methoxy-thiazolo[5,4-b]pyridin-2-ylamine give 3-(4,4-difluorocyclohexyl)-2-(5,5-dioxo-5,10-dihydrophenothiazin-2-yl)-N-(5-methoxythiazolo[5,4-b]pyridin-2-yl)propionamide.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07732440B2 |
| 出典データセット | uspto-grants-2010_06 |
| ORD ID | ord-3958a078b667471db485796a4948a9a2 |
| 出典メモ | uspto-grants-2010_06 |