Methanol → 2-Chloro-4-hydrazinylpyrimidine

HRID 1500375ノート

反応式

HRID 1500375 の反応式
[Cl:1][C:2]1[N:7]=[C:6](Cl)[CH:5]=[CH:4][N:3]=1.[NH2:9][NH2:10].CO.C(Cl)Cl>CCO>[Cl:1][C:2]1[N:7]=[C:6]([NH:9][NH2:10])[CH:5]=[CH:4][N:3]=1

参加物

6

反応物 4

HCID 887MethanolHCID 6344DichloromethaneHCID 9321HydrazineHCID 775312,4-Dichloropyrimidine

生成物 1

HCID 160921982-Chloro-4-hydrazinylpyrimidine収率 94.8%

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒

実験手順

A solution of 2,4-dichloropyrimidine (2.0 g) in EtOH (25 mL) was cooled to 0-20° C. and treated with hydrazine (2.8 mL). The progress of the reaction was followed by TLC using 10% MeOH:CH2Cl2 as mobile phase and visualizing under UV light. The mixture was concentrated under reduced pressure to afford 3.1 g of crude 2-chloro-4-hydrazinyl-pyrimidine (yield=94.8%).

後処理

  1. concentrationThe mixture was concentrated under reduced pressure

出典と根拠

ORDレコード
ord-309966fb13c842c1a31dab76d2ddba89
出典データセット
uspto-grants-2015_12
特許番号
US09206158B2

反応ノート

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