2-(Isopropylthio)aniline → N-(2-(isopropylthio)phenyl)-3-methyl-6-(methylthio)-1H-pyrazolo[3,4-d]pyrimidin-4-amine

HRID 1500457ノート

反応式

HRID 1500457 の反応式
Cl[C:2]1[N:7]=[C:6]([S:8][CH3:9])[N:5]=[C:4]2[NH:10][N:11]=[C:12]([CH3:13])[C:3]=12.[CH:14]([S:17][C:18]1[CH:24]=[CH:23][CH:22]=[CH:21][C:19]=1[NH2:20])([CH3:16])[CH3:15]>C(O)(C)C>[CH:14]([S:17][C:18]1[CH:24]=[CH:23][CH:22]=[CH:21][C:19]=1[NH:20][C:2]1[N:7]=[C:6]([S:8][CH3:9])[N:5]=[C:4]2[NH:10][N:11]=[C:12]([CH3:13])[C:3]=12)([CH3:16])[CH3:15]

参加物

4

反応物 2

HCID 138527202-(Isopropylthio)anilineHCID 1785034684-Chloro-3-methyl-6-(methylthio)-1H-pyrazolo[3,4-d]pyrimidine

生成物 1

HCID 178503488N-(2-(isopropylthio)phenyl)-3-methyl-6-(methylthio)-1H-pyrazolo[3,4-d]pyrimidin-4-amine

試薬・触媒・溶媒 1

HCID 3776Isopropanol溶媒

実験手順

A mixture of 4-chloro-3-methyl-6-methylmercaptopyrazolo[3,4-d]pyrimidine (A-3) (1.21 g, 5.63 mmol) and 2-(isopropylthio)aniline (A-4) (1.42 g, 8.50 mmol) in isopropanol (56 mL) was stirred at reflux for 3 h. After cooling down to ambient temperature, TEA (0.78 mL, 5.66 mmol) was added to the mixture, and the solution was again heated to reflux for 0.5 h. After cooling down to ambient temperature, the mixture was filtered to give the title compound (A-5) as white solid (1.30 g, 3.77 mmol). MS-ESI (m/z): 346 (M+H)+.

後処理

  1. temperatureat reflux for 3 h
  2. temperaturethe solution was again heated
  3. temperatureto reflux for 0.5 h
  4. temperatureAfter cooling down to ambient temperature
  5. filtrationthe mixture was filtered

出典と根拠

ORDレコード
ord-dd303b6baf284962a61fa365e36357c6
出典データセット
uspto-grants-2015_12
特許番号
US09206166B2

反応ノート

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