Hydrochloric Acid → 3-Propargyl-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidine-2,4-dione hydrochloride

反応式

C(OC([N:8]1[CH2:22][CH2:21][C:11]2[NH:12][C:13](=[O:20])[N:14]([CH2:17][C:18]#[CH:19])[C:15](=[O:16])[C:10]=2[CH2:9]1)=O)(C)(C)C.[ClH:23]>C(OCC)(=O)C.C(O)C>[ClH:23].[CH2:17]([N:14]1[C:15](=[O:16])[C:10]2[CH2:9][NH:8][CH2:22][CH2:21][C:11]=2[NH:12][C:13]1=[O:20])[C:18]#[CH:19]

参加物

実験手順

6-(tert-Butoxycarbonyl)-3 propargyl-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidine-2,4-dione (1.0 g) was suspended in 4 N hydrochloric acid in ethyl acetate (10 ml) and the resultant mixture was stirred at room temperature for 3 hours. A precipitate was obtained by filtration and dissolved in ethanol and the solvent was distilled away under reduced pressure. This was repeated three times to obtain the titled compound (790 mg) as a colorless amorphous substance. The resultant compound was subjected to a next reaction without further purifying.