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Hydrochloric Acid → N-[(3R)-1-(Aminoacetyl)piperidin-3-yl]-6-pyrazolo[1,5-a]pyridin-3-ylpyrazin-2-amine

HRID 1500783
ノート
印刷プレビュー

反応式

HRID 1500783 の反応式
Cl.[O:2]=[C:3]([N:13]1[CH2:18][CH2:17][CH2:16][C@@H:15]([NH:19][C:20]2[CH:25]=[N:24][CH:23]=[C:22]([C:26]3[CH:27]=[N:28][N:29]4[CH:34]=[CH:33][CH:32]=[CH:31][C:30]=34)[N:21]=2)[CH2:14]1)[CH2:4][NH:5]C(=O)OC(C)(C)C>O1CCOCC1.CO>[NH2:5][CH2:4][C:3]([N:13]1[CH2:18][CH2:17][CH2:16][C@@H:15]([NH:19][C:20]2[CH:25]=[N:24][CH:23]=[C:22]([C:26]3[CH:27]=[N:28][N:29]4[CH:34]=[CH:33][CH:32]=[CH:31][C:30]=34)[N:21]=2)[CH2:14]1)=[O:2]
参加物実験手順後処理出典と根拠反応ノート

参加物

5

反応物 2

HCID 313Hydrochloric AcidHCID 86691788Tert-Butyl (2-oxo-2-{(3R)-3-[(6-pyrazolo[1,5-a]pyridin-3-ylpyrazin-2-yl)amino]piperidin-1-yl}ethyl)carbamate

生成物 1

HCID 53373775N-[(3R)-1-(Aminoacetyl)piperidin-3-yl]-6-pyrazolo[1,5-a]pyridin-3-ylpyrazin-2-amine収率 95%

試薬・触媒・溶媒 2

HCID 887Methanol溶媒HCID 312751,4-Dioxane
溶媒

実験手順

A solution of hydrochloric acid in dioxane (4M, 10 mL) was added to a solution of tert-butyl (2-oxo-2-{(3R)-3-[(6-pyrazolo[1,5-a]pyridin-3-ylpyrazin-2-yl)amino]piperidin-1-yl}ethyl)carbamate (Preparation 38, 88 mg, 0.23 mmol) in methanol (3 mL) and the resulting mixture was stirred at ambient temperature for one hour. The solvents were then evaporated to half of their volume and the yellow solid that precipitated was filtered, washed with diethyl ether and dried to give the title compound (76 mg, 95%).

後処理

  1. customThe solvents were then evaporated to half of their volume
  2. customthe yellow solid that precipitated
  3. filtrationwas filtered
  4. washwashed with diethyl ether
  5. customdried

出典と根拠

ORDレコード
ord-2b61ceb6c94345158ab34b14284a0367
出典データセット
uspto-grants-2015_12
DOI
10.6084/m9.figshare.5104873.v1
特許番号
US09206183B2

反応ノート

読み込み中…

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