1-(4-Bromo-3-methylphenyl)ethanol → 1-(4-Bromo-3-methylphenyl)ethanone
反応式
[Cr](Cl)([O-])(=O)=O.[NH+]1C=CC=CC=1.[Br:12][C:13]1[CH:18]=[CH:17][C:16]([CH:19]([OH:21])[CH3:20])=[CH:15][C:14]=1[CH3:22]>ClCCl>[Br:12][C:13]1[CH:18]=[CH:17][C:16]([C:19](=[O:21])[CH3:20])=[CH:15][C:14]=1[CH3:22]参加物
4
実験手順
Pyridinium chlorochromate (48 g, 223 mmol) was added to a solution of 1-(4-bromo-3-methylphenyl)ethanol (31.9 g, 148 mmol) in dichloromethane (800 mL). The mixture was stirred at room temperature for 2 hours. The mixture was concentrated to give a residue. The residue was purified by column chromatography (silica gel, petroleum ether/ethyl acetate=25:1) to give 1-(4-bromo-3-methylphenyl)ethanone (27.3 g, 87%).
後処理
- concentrationThe mixture was concentrated
- customto give a residue
- customThe residue was purified by column chromatography (silica gel, petroleum ether/ethyl acetate=25:1)
出典と根拠
- ORDレコード
- ord-2810b3904ff94b9bb84dea21a46d0f3b
- 出典データセット
- uspto-grants-2015_12
- 特許番号
- US09206128B2
反応ノート
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