2-Amino-6-methyl-4-oxo-4H-pyran-3-carbonitrile → HCID 178429083、化合物

HRID 1501260ノート

反応式

HRID 1501260 の反応式
[NH2:1][C:2]1[O:3][C:4]([CH3:11])=[CH:5][C:6](=[O:10])[C:7]=1[C:8]#[N:9]>Cl>[OH:3][C:2]1[N:1]=[C:4]([CH3:11])[CH:5]=[C:6]([OH:10])[C:7]=1[C:8]#[N:9]

参加物

3

反応物 1

HCID 114805352-Amino-6-methyl-4-oxo-4H-pyran-3-carbonitrile

生成物 1

HCID 178429083HCID 178429083、化合物収率 83.3%

試薬・触媒・溶媒 1

HCID 313Hydrochloric Acid溶媒

実験手順

A suspension of 2-amino-6-methyl-4-oxo-4H-pyran-3-carbonitrile (6.0 g, 40 mmol) in 10% hydrochloric acid (60 mL) was heated under reflux for 4 hours. The precipitate was collected by filtration and washed with water, and then recrystallized from methanol to give 2,4-dihydroxy-6-methylnicotinonitrile (5.0 g, 80%) as a brown solid. 1H NMR (300 MHz, CD3OD): δ 12.44-12.46 (m, 1H), 11.69 (s, 1H), 5.85 (s, 1H), 2.15 (s, 3H).

後処理

  1. temperaturewas heated
  2. temperatureunder reflux for 4 hours
  3. filtrationThe precipitate was collected by filtration
  4. washwashed with water
  5. customrecrystallized from methanol

出典と根拠

ORDレコード
ord-d09f9d1f219f4637b09343b97921bd22
出典データセット
uspto-grants-2015_12
特許番号
US09206128B2

反応ノート

読み込み中…