Boron tribromide → 2,6-Difluoro-3-hydroxybenzonitrile

HRID 1502009ノート

反応式

HRID 1502009 の反応式
[F:1][C:2]1[C:9]([O:10]C)=[CH:8][CH:7]=[C:6]([F:12])[C:3]=1[C:4]#[N:5].B(Br)(Br)Br>C(Cl)Cl>[F:1][C:2]1[C:9]([OH:10])=[CH:8][CH:7]=[C:6]([F:12])[C:3]=1[C:4]#[N:5]

参加物

4

反応物 2

HCID 25134Boron tribromideHCID 37918322,6-Difluoro-3-methoxybenzonitrile

生成物 1

HCID 451191012,6-Difluoro-3-hydroxybenzonitrile

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒

実験手順

2,6-difluoro-3-methoxybenzonitrile (4.42 g, 26.1 mmol) was dissolved in DCM (10 mL) at 0° C. then 1 M BBr3 (52.2 mL, 52.2 mmol) was added. The reaction mixture was then warmed up to RT and stirred overnight. The reaction mixture was poured into ice water and extracted with more DCM. The organic layer was separated, dried over Na2SO4, filtered, and evaporated to dryness to yield 2,6-difluoro-3-hydroxybenzonitrile: LC-MS: M+1=156.

後処理

  1. extractionextracted with more DCM
  2. customThe organic layer was separated
  3. dry with materialdried over Na2SO4
  4. filtrationfiltered
  5. customevaporated to dryness

出典と根拠

ORDレコード
ord-8c287bd2ca46486b80208d0799ea52f3
出典データセット
uspto-grants-2015_12
特許番号
US09206199B2

反応ノート

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