Acetyl chloride → HCID 86680933、化合物

反応式

Cl.[CH3:2][O:3][C:4]([CH:6]1[NH:10][CH:9]([C:11]([O:13][CH3:14])=[O:12])[CH2:8][S:7]1)=[O:5].[C:15](Cl)(=[O:17])[CH3:16].C(N(CC)CC)C>>[CH3:2][O:3][C:4]([CH:6]1[N:10]([C:15](=[O:17])[CH3:16])[CH:9]([C:11]([O:13][CH3:14])=[O:12])[CH2:8][S:7]1)=[O:5]

参加物

反応物 3

HCID 6367Acetyl chloride

HCID 8471Triethylamine

HCID 86680931HCID 86680931、化合物

生成物 1

HCID 86680933HCID 86680933、化合物

実験手順

Thiazolidine-2,4-dicarboxylic acid 2,4-dimethyl ester hydrochloride (0.50 g, 2.07 mmol) was subjected to acylation with acetyl chloride (0.22 ml, 3.09 mmol) in the presence of triethylamine (0.58 ml, 4.17 mmol) to give N-acetylthiazolidine-2,4-dicarboxylic acid 2,4-dimethyl ester (with the ratio of two kinds of stereoisomers of about 49:51 as confirmed by NMR) as a pale-yellow oil (0.42 g, 83.0%).

出典と根拠

ORDレコード: ord-08f406401d7046e88447df647566b4b4
出典データセット: uspto-grants-2015_12
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US09212154B2

反応ノート

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