Ethyl 2-(4-chlorobenzyl)acetoacetate → HCID 178423487、化合物

反応式

[NH:1]([C:3]1[NH:7][C:6]2[CH:8]=[CH:9][C:10]([CH3:12])=[CH:11][C:5]=2[N:4]=1)[NH2:2].[C:13]([CH:16]([CH2:22][C:23]1[CH:28]=[CH:27][C:26]([Cl:29])=[CH:25][CH:24]=1)[C:17](OCC)=[O:18])(=O)[CH3:14]>>[Cl:29][C:26]1[CH:25]=[CH:24][C:23]([CH2:22][C:16]2[C:13]([CH3:14])=[N:2][N:1]([C:3]3[NH:7][C:6]4[CH:8]=[CH:9][C:10]([CH3:12])=[CH:11][C:5]=4[N:4]=3)[C:17]=2[OH:18])=[CH:28][CH:27]=1

参加物

反応物 2

HCID 2757404Ethyl 2-(4-chlorobenzyl)acetoacetate

HCID 178423496HCID 178423496、化合物

生成物 1

HCID 178423487HCID 178423487、化合物

実験手順

Using 2-hydrazino-5-methyl-1H-benzimidazole (4) obtained in Example 1, step 3 and ethyl 2-acetyl-3-(4-chlorophenyl)propanoate (31), and by a method similar to that in Example 1, step 4, 4-[(4-chlorophenyl)methyl]-3-methyl-1-(5-methyl-1H-benzimidazol-2-yl)-1H-pyrazol-5-ol (32) was obtained.

出典と根拠

ORDレコード: ord-e35eeaa561114b72983692fcc174ce47
出典データセット: uspto-grants-2015_12
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US09212169B2

反応ノート

読み込み中…