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Acetone → Bazedoxifene
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Acetone | HCID 180 | — |
| 反応物 | Azepane | HCID 8119 | — |
| 反応物 | bazedoxifene 5-Benzyloxy-2(4-benzyloxyphenyl)-1-[4-(2-bromoethoxy)benzyl]-3-methyl-indole | HCID 131734316 | — |
| 溶媒 | Acetic Acid | HCID 176 | — |
| 生成物 | Bazedoxifene | HCID 154257 | — |
反応手順
European Patent Application No. 0802183 describes a synthesis of bazedoxifene 5-Benzyloxy-2(4-benzyloxyphenyl)-1-[4-(2-bromoethoxy)benzyl]-3-methyl-indole is reacted with azepan, under suitable reaction conditions, followed by deprotection to yield bazedoxifene, which on subsequent treatment with acetone and acetic acid gives bazedoxifene acetate.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US09212172B2 |
| 出典データセット | uspto-grants-2015_12 |
| ORD ID | ord-30e213a5c70c49b3815a389b696eeaac |
| 出典メモ | uspto-grants-2015_12 |