化工社化工社 化学情報印刷レポート · 研究参考用
tert-Butyl methyl ether → Bazedoxifene Acetate
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | tert-Butyl methyl ether | HCID 15413 | — |
| 反応物 | Bazedoxifene | HCID 154257 | — |
| 溶媒 | Acetic Acid | HCID 176 | — |
| 生成物 | Bazedoxifene Acetate | HCID 154256 | — |
反応手順
Bazedoxifene free base (400 mg) and methyl tert-butyl ether (30 mL) are mixed and stirred for about 10 minutes. Acetic acid (0.17 g) is added slowly through a dropper and the mixture is stirred overnight for solid formation. The solid is collected by filtration to afford 250 mg of crystalline bazedoxifene acetate Form D.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US09212172B2 |
| 出典データセット | uspto-grants-2015_12 |
| ORD ID | ord-b6ac894438f44dbcbe6c1b754deae012 |
| 出典メモ | uspto-grants-2015_12 |