Benzenesulfonic acid, 4-methyl-, compd. with pyridine (1:1) → 4-benzyloxy-1-(4-hydroxyphenyl)-1H-pyridin-2-one

HRID 15035

反応式

HRID 15035 の反応式
C1(C)C=CC(S([O-])(=O)=O)=CC=1.[NH+]1C=CC=CC=1.[CH2:18]([O:25][C:26]1[CH:31]=[CH:30][N:29]([C:32]2[CH:37]=[CH:36][C:35]([O:38]C3CCCCO3)=[CH:34][CH:33]=2)[C:28](=[O:45])[CH:27]=1)[C:19]1[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=1>C(O)C>[CH2:18]([O:25][C:26]1[CH:31]=[CH:30][N:29]([C:32]2[CH:33]=[CH:34][C:35]([OH:38])=[CH:36][CH:37]=2)[C:28](=[O:45])[CH:27]=1)[C:19]1[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=1

参加物

4

反応物 2

HCID 466102Benzenesulfonic acid, 4-methyl-, compd. with pyridine (1:1)HCID 684306714-benzyloxy-1-{4-[(2-tetrahydropyranyl)oxy]phenyl}-1H-pyridin-2-one

生成物 1

HCID 684312834-benzyloxy-1-(4-hydroxyphenyl)-1H-pyridin-2-one収率 98%

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒

実験手順

Pyridinium p-toluenesulfonate (65 mg) was added to an ethanol solution (16 mL) of 4-benzyloxy-1-{4-[(2-tetrahydropyranyl)oxy]phenyl}-1H-pyridin-2-one (982 mg, 2.60 mmols) and refluxed for an hour. The reaction liquid was cooled to room temperature and the precipitate was recovered by filtration and washed with water and ethyl acetate to provide the title compound (746 mg, 98%).

後処理

  1. temperaturerefluxed for an hour
  2. customThe reaction liquid
  3. filtrationthe precipitate was recovered by filtration
  4. washwashed with water and ethyl acetate

出典と根拠

ORDレコード
ord-7d8e8bb1d0ff40a88da8478839fb9b50
出典データセット
uspto-grants-2010_06
特許番号
US07732456B2

関連ノート

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