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4-Fluorobenzyl bromide → 4-(4-Fluorobenzyloxy)-1-{5-[2-(1-piperidinyl)-ethoxy]pyridin-2-yl}-1H-pyridin-2-one
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 4-Fluorobenzyl bromide | HCID 68021 | — |
| 反応物 | 4-benzyloxy-1-{4-[2-(1-piperidinyl)ethoxy]phenyl}-1H-pyridin-2-one | HCID 24780883 | — |
| 反応物 | 4-benzyloxy-1-{5-[2-(1-piperidinyl)ethoxy]pyridin-2-yl}-1H-pyridin-2-one | HCID 58964920 | — |
| 反応物 | (6-Fluoropyridin-3-yl)methyl methanesulphonate | HCID 86614892 | — |
| 生成物 | 4-(4-Fluorobenzyloxy)-1-{5-[2-(1-piperidinyl)-ethoxy]pyridin-2-yl}-1H-pyridin-2-one | HCID 58964908 | — |
反応手順
Example 25 was repeated except that 4-benzyloxy-1-{4-[2-(1-piperidinyl)ethoxy]phenyl}-1H-pyridin-2-one and 2-fluoro-5-methanesulfonyloxymethylpyridine were replaced with 4-benzyloxy-1-[5-(2-piperidin-1-ylethoxy)pyridin-2-yl]-1H-piridin-2-one (Example 20) and 4-fluorobenzyl bromide, to provide the title compound.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07732456B2 |
| 出典データセット | uspto-grants-2010_06 |
| ORD ID | ord-0543ca1c38814e0b8f306d13950ad005 |
| 出典メモ | uspto-grants-2010_06 |