Dichloromethane → 5-(3-chloropropyl)-2-methyl-5H-furo[3,2-c]pyridin-4-one

反応式

CS(Cl)(=O)=O.Cl[CH2:7][Cl:8].OC[CH2:11][CH2:12][N:13]1[CH:18]=[CH:17][C:16]2[O:19][C:20]([CH3:22])=[CH:21][C:15]=2[C:14]1=[O:23]>C(N(CC)CC)C>[Cl:8][CH2:7][CH2:11][CH2:12][N:13]1[CH:18]=[CH:17][C:16]2[O:19][C:20]([CH3:22])=[CH:21][C:15]=2[C:14]1=[O:23]

参加物

実験手順

Methane sulfonyl chloride(0.24 ml) was added to a dichloromethane solution(10 ml) of 5-(3-hydroxypropyl)-2-methyl-5H-furo[3,2-c]pyridine-4-one (0.28 g) and triethylamine(0.45 ml). The mixture was stirred at room temperature for two days. The reaction liquid was condensed under reduced pressure. The residue was purified by silica gel column chromatography (ethyl acetate: hexane=1:4→1:1). The purified product was condensed to dryness under reduced pressure to give the title compound(0.16 g) as a white amorphous solid.