4-tert-Butoxycarbonylamino-1-(5-aminocarbonyl-2-pyridyl)piperidine → 6-(4-Aminopiperidin-1-yl)nicotinamide hydrochloride
反応式
[ClH:1].CCOC(C)=O.[C:8]([C:11]1[CH:12]=[CH:13][C:14]([N:17]2[CH2:22][CH2:21][CH:20]([NH:23]C(=O)OC(C)(C)C)[CH2:19][CH2:18]2)=[N:15][CH:16]=1)(=[O:10])[NH2:9]>>[ClH:1].[NH2:23][CH:20]1[CH2:19][CH2:18][N:17]([C:14]2[CH:13]=[CH:12][C:11]([C:8]([NH2:9])=[O:10])=[CH:16][N:15]=2)[CH2:22][CH2:21]1参加物
3
実験手順
To a stirred solution of HCl/EtOAc (9 ml, 3N) was added tert-butyl 1-(5-carbamoylpyridin-2-yl)piperidin-4-ylcarbamate (400 mg) and the mixture was stirred at room temperature for 4 h. The solid was collected by filtration and washed with EtOAc to give a white solid (300 mg, 94%). [LCMS RtA=0.85 min, [M+H]+=221.1].
後処理
- filtrationThe solid was collected by filtration
- washwashed with EtOAc
出典と根拠
- ORDレコード
- ord-ba454e5f155b49ab89d268765bc670e2
- 出典データセット
- uspto-grants-2015_12
- 特許番号
- US09216182B2
反応ノート
読み込み中…