Dichloromethane → 4,5-dibromo-2-(4-hydroxyphenyl)-2H-pyridazin-3-one
反応式
ClCCl.B(Br)(Br)Br.[Br:8][C:9]1[C:10](=[O:24])[N:11]([C:16]2[CH:21]=[CH:20][C:19]([O:22]C)=[CH:18][CH:17]=2)[N:12]=[CH:13][C:14]=1[Br:15]>O>[Br:8][C:9]1[C:10](=[O:24])[N:11]([C:16]2[CH:17]=[CH:18][C:19]([OH:22])=[CH:20][CH:21]=2)[N:12]=[CH:13][C:14]=1[Br:15]参加物
5
実験手順
A 1N dichloromethane solution (5.5 mL) of boron tribromide was added to a dichloromethane solution (30 mL) of 4,5-dibromo-2-(4-methoxyphenyl)-2H-pyridazin-3-one (1.1 g, 3.06 mmols), and stirred overnight at room temperature. Water (30 mL) was added and stirred for 30 minutes. The resulting precipitate was recovered by filtration, washed with water and chloroform and dried to provide the title compound (1.03 g, 97%).
後処理
- stirringstirred for 30 minutes
- filtrationThe resulting precipitate was recovered by filtration
- washwashed with water and chloroform
- customdried
出典と根拠
- ORDレコード
- ord-3d9d0cf7ddde471781a2540f0cc9ffef
- 出典データセット
- uspto-grants-2010_06
- 特許番号
- US07732456B2
反応ノート
読み込み中…