Cesium carbonate → tert-butyl rel-[(3S,4S)-3-({6-cyano-5-[(4-methoxy-6-methylpyridin-2-yl)amino]pyridin-3-yl}amino)-1,1-dioxidotetrahydro-2H-thiopyran-4-yl]carbamate

反応式

Br[C:2]1[CH:3]=[C:4]([NH:10][C@H:11]2[C@@H:16]([NH:17][C:18](=[O:24])[O:19][C:20]([CH3:23])([CH3:22])[CH3:21])[CH2:15][CH2:14][S:13](=[O:26])(=[O:25])[CH2:12]2)[CH:5]=[N:6][C:7]=1[C:8]#[N:9].[CH3:27][O:28][C:29]1[CH:34]=[C:33]([CH3:35])[N:32]=[C:31]([NH2:36])[CH:30]=1.C(=O)([O-])[O-].[Cs+].[Cs+]>C1C=CC(/C=C/C(/C=C/C2C=CC=CC=2)=O)=CC=1.C1C=CC(/C=C/C(/C=C/C2C=CC=CC=2)=O)=CC=1.C1C=CC(/C=C/C(/C=C/C2C=CC=CC=2)=O)=CC=1.[Pd].[Pd]>[C:8]([C:7]1[N:6]=[CH:5][C:4]([NH:10][C@H:11]2[C@@H:16]([NH:17][C:18](=[O:24])[O:19][C:20]([CH3:23])([CH3:22])[CH3:21])[CH2:15][CH2:14][S:13](=[O:26])(=[O:25])[CH2:12]2)=[CH:3][C:2]=1[NH:36][C:31]1[CH:30]=[C:29]([O:28][CH3:27])[CH:34]=[C:33]([CH3:35])[N:32]=1)#[N:9]