Ammonium Hydroxide → HCID 54549569、化合物
反応式
[NH2:1][C:2]1[CH:7]=[CH:6][C:5]([CH2:8][CH2:9][CH2:10][C:11]([O:13]C)=O)=[CH:4][CH:3]=1.[NH4+:15].[OH-]>CO>[NH2:1][C:2]1[CH:7]=[CH:6][C:5]([CH2:8][CH2:9][CH2:10][C:11]([NH2:15])=[O:13])=[CH:4][CH:3]=1参加物
4
実験手順
To a solution of compound 27 (300 mg, 1.55 mmol) in CH3OH (5 mL) was added NH4OH (32) at room temperature with stirring. The reaction mixture was stirred at room temperature for 6 h and concentrated in vacuo. The residue was diluted with water and extracted with DCM/CH3OH (10:1). The combined organic layers were dried over Na2SO4 and concentrated to dryness to give compound 33 (194 mg, 70%) as a white solid. The crude product was used directly for the next step without purification.
後処理
- stirringThe reaction mixture was stirred at room temperature for 6 h
- concentrationconcentrated in vacuo
- additionThe residue was diluted with water
- extractionextracted with DCM/CH3OH (10:1)
- dry with materialThe combined organic layers were dried over Na2SO4
- concentrationconcentrated to dryness
出典と根拠
- ORDレコード
- ord-dfc911b0f96a4bae878ba53802b70ee4
- 出典データセット
- uspto-grants-2015_12
- 特許番号
- US09216957B2
反応ノート
読み込み中…