2-Chloro-6-(trifluoromethyl)nicotinonitrile → 2-Methoxy-6-(trifluoromethyl)pyridine-3-carbonitrile

HRID 1505221ノート

反応式

HRID 1505221 の反応式
Cl[C:2]1[N:9]=[C:8]([C:10]([F:13])([F:12])[F:11])[CH:7]=[CH:6][C:3]=1[C:4]#[N:5].[CH3:14][O-:15].[Na+]>CO>[CH3:14][O:15][C:2]1[C:3]([C:4]#[N:5])=[CH:6][CH:7]=[C:8]([C:10]([F:13])([F:12])[F:11])[N:9]=1

参加物

4

反応物 2

HCID 27784132-Chloro-6-(trifluoromethyl)nicotinonitrileHCID 10942334Sodium Methoxide

生成物 1

HCID 588734072-Methoxy-6-(trifluoromethyl)pyridine-3-carbonitrile収率 97%

試薬・触媒・溶媒 1

HCID 887Methanol溶媒

反応条件

温度
60 °C

実験手順

To 2-chloro-6-trifluoromethyl-nicotinonitrile (0.5 g, 2.4 mmol) in methanol (30 mL) was added sodium methylate in small portion (2 mol eq, 0.26 g). The reaction mixture was heated at 60° C. overnight. The solvent was distilled under reduced pressure and water was added to the residue. The aqueous solution was extracted with EtOAc (3×25 mL) and the organic phases were evaporated at reduced pressure to give 28c as a pale yellow oil (0.48 g, 2.33 mmol, 97% Yield). 1HNMR (DMSO, 200 MHz) δ 4.04 (s, 3H), 7.71 (d, 1H, J=6), 8.59 (d, 1H, J=6).

後処理

  1. distillationThe solvent was distilled under reduced pressure and water
  2. additionwas added to the residue
  3. extractionThe aqueous solution was extracted with EtOAc (3×25 mL)
  4. customthe organic phases were evaporated at reduced pressure

出典と根拠

ORDレコード
ord-461cfd0ea51d49a0828e8e93572e682f
出典データセット
uspto-grants-2015_12
特許番号
US09216975B2

反応ノート

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