N1-(4-{[2-methyl-5-(methyloxy)phenyl]oxy}phenyl)-D-alaninamide → (5R)-5-methyl-3-(6-{[2-methyl-5-(methyloxy)phenyl]oxy}-3-pyridinyl)-2,4-imidazolidinedione
反応式
CC1C=C[C:5]([O:8]C)=CC=1OC1C=CC(NC(=O)[C@@H](C)N)=CC=1.[CH3:23][C:24]1[CH:29]=[CH:28][C:27]([O:30][CH3:31])=[CH:26][C:25]=1[O:32][C:33]1[N:38]=[CH:37][C:36]([NH:39][C:40](=[O:44])[C@@H:41]([CH3:43])[NH2:42])=[CH:35][CH:34]=1>>[CH3:43][C@H:41]1[NH:42][C:5](=[O:8])[N:39]([C:36]2[CH:37]=[N:38][C:33]([O:32][C:25]3[CH:26]=[C:27]([O:30][CH3:31])[CH:28]=[CH:29][C:24]=3[CH3:23])=[CH:34][CH:35]=2)[C:40]1=[O:44]参加物
3
実験手順
The title compound was made in a similar fashion to the preparation of Example 7 replacing N1-(4-{[2-methyl-5-(methyloxy)phenyl]oxy}phenyl)-D-alaninamide with N1-(6-{[2-methyl-5-(methyloxy)phenyl]oxy}-3-pyridinyl)-D-alaninamide (Intermediate 56, 118 mg) to afford the title compound (78 mg)
出典と根拠
- ORDレコード
- ord-cafcfa74aa9346f6be93e0ae24c89e21
- 出典データセット
- uspto-grants-2015_12
- DOI