Potassium Carbonate → (3R,3aS,6aR)-hexahydrofuro(2,3-b)furan-3-ol
反応式
C([O:4][C@@H:5]1[C@H:12]2[C@H:8]([O:9][CH2:10][CH2:11]2)[O:7][CH2:6]1)(=O)C.C(=O)([O-])[O-].[K+].[K+]>CO.ClCCl>[O:7]1[C@H:8]2[O:9][CH2:10][CH2:11][C@H:12]2[C@@H:5]([OH:4])[CH2:6]1参加物
5
反応条件
- 温度
- 30 °C
実験手順
(3R,3aS,6aR)-Hexahydrofuro[2,3-b]furan-3-yl acetate (II, 14.0 g) was dissolved in methanol (42 mL). Potassium carbonate (0.34 g) was added and stirred at 25-35° C. for 6-8 hours. Methanol Was distilled out completely under vacuum, to the distillate methylenedichloride (28 mL) was added, stirred the mass for 30 minutes and again distilled the solvent to get residue. Dissolved the residue in dichloromethane (56 mL), the resultant solution was treated with carbon and the solvent was completely distilled out get title compound I (yield 10.5 g).
後処理
- distillationMethanol Was distilled out completely under vacuum, to the distillate methylenedichloride (28 mL)
- additionwas added
- stirringstirred the mass for 30 minutes
- distillationagain distilled the solvent
- customto get residue
- distillationthe solvent was completely distilled out
出典と根拠
- ORDレコード
- ord-55ddae41e48d4439bdad97b451074da2
- 出典データセット
- uspto-grants-2015_12
- 特許番号
- US09216990B2
反応ノート
読み込み中…