1-Tetralone → (R)-(-)-1,2,3,4-Tetrahydro-1-naphthol
反応式
[CH2:1]1[CH2:11][C:9](=[O:10])[C:8]2[C:3](=[CH:4][CH:5]=[CH:6][CH:7]=2)[CH2:2]1.[H][H]>CO>[CH2:1]1[CH2:2][C:3]2[C:8](=[CH:7][CH:6]=[CH:5][CH:4]=2)[C@H:9]([OH:10])[CH2:11]1参加物
4
反応条件
- 温度
- 60 °C
実験手順
In a 50-ml autoclave, 3.3 mg (0.005 mmol, S/C=1000) of RuCl((R,R)—O-HT-Tsdpen) was placed, and the autoclave was purged with nitrogen. Subsequently, 0.73 g (5.0 mmol) of α-tetralone and 4.4 ml of methanol were added thereto, then hydrogen gas was charged to 3.0 MPa. Subsequently, the mixture was stirred for 20 hours at 60° C. The reaction liquid was subjected to a GC analysis, and as a result, (R)-1-tetralol was obtained at a conversion rate of 52.0% with an optical purity of 99.3% ee.
後処理
- customthe autoclave was purged with nitrogen
- customThe reaction liquid
出典と根拠
- ORDレコード
- ord-9e1619e5fdec4a0fb3d5b331b51739e9
- 出典データセット
- uspto-grants-2015_12
- 特許番号
- US09217005B2
反応ノート
読み込み中…