Hydrogen chloride-ethyl acetate → HCID 90229289、化合物
反応式
[Cl:1][C:2]1[C:3]([CH3:45])=[C:4]([NH:8][C:9]([C:11]2[C:19]3[N:18]=[C:17]([C@@H:20]4[CH2:24][CH2:23][CH2:22][N:21]4C(OC(C)(C)C)=O)[NH:16][C:15]=3[CH:14]=[C:13]([NH:32][C:33]([C:35]3[CH:40]=[CH:39][CH:38]=[CH:37][C:36]=3[C:41]([F:44])([F:43])[F:42])=[O:34])[CH:12]=2)=[O:10])[CH:5]=[CH:6][CH:7]=1.[ClH:46].C(OCC)(=O)C>C(OCC)(=O)C>[ClH:1].[ClH:46].[Cl:1][C:2]1[C:3]([CH3:45])=[C:4]([NH:8][C:9]([C:11]2[C:19]3[N:18]=[C:17]([C@@H:20]4[CH2:24][CH2:23][CH2:22][NH:21]4)[NH:16][C:15]=3[CH:14]=[C:13]([NH:32][C:33]([C:35]3[CH:40]=[CH:39][CH:38]=[CH:37][C:36]=3[C:41]([F:44])([F:42])[F:43])=[O:34])[CH:12]=2)=[O:10])[CH:5]=[CH:6][CH:7]=1参加物
4
実験手順
To a solution of tert-butyl (2S)-2-{4-[(3-chloro-2-methylphenyl)carbamoyl]-6-({[2-(trifluoromethyl)phenyl]carbonyl}amino)-1H-benzimidazole-2-yl}pyrrolidine-1-carboxylate (26 mg) (Example 69) in ethyl acetate (2 mL), was added 4N hydrogen chloride/ethyl acetate solution (2 mL), and the mixture was stirred at room temperature for 2 hours. N-hexane was added to the reaction mixture, the precipitate was collected, and dried to obtain the titled compound (20 mg) as pale yellow powder.