化工社化工社 化学情報印刷レポート · 研究参考用
2,3-Diaminobenzoic acid methyl ester → Methyl 2-(2-ethoxy-2-oxoethyl)-1H-benzimidazole-4-carboxylate
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 2,3-Diaminobenzoic acid methyl ester | HCID 571825 | — |
| 反応物 | Ethyl beta-amino-beta-ethoxyacrylate hydrochloride | HCID 53395434 | — |
| 溶媒 | Ethanol | HCID 702 | — |
| 生成物 | Methyl 2-(2-ethoxy-2-oxoethyl)-1H-benzimidazole-4-carboxylate | HCID 90229347 | 106.2% |
反応手順
A solution of methyl 2,3-diaminobenzoate (680 mg) and ethyl 3-amino-3-ethoxyacrylate hydrochloride (880 mg) in EtOH (12 mL) was stirred at 60° C. for 2 hours. EtOH was removed under reduced pressure, and the residue was purified on column chromatography to obtain the titled compound (1.14 g) as a pale yellow solid.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US09216968B2 |
| 出典データセット | uspto-grants-2015_12 |
| ORD ID | ord-1b90bd2e121847489527c70af599b16e |
| 出典メモ | uspto-grants-2015_12 |