Methanesulfonic Acid → HCID 90229562、化合物
反応式
[CH3:1][S:2]([OH:5])(=[O:4])=[O:3].[Cl:6][C:7]1[C:8]([CH3:41])=[C:9]([NH:13][C:14]([C:16]2[C:24]3[N:23]=[C:22]([CH2:25][O:26][CH3:27])[NH:21][C:20]=3[CH:19]=[C:18]([NH:28][C:29]([C:31]3[CH:36]=[CH:35][CH:34]=[CH:33][C:32]=3[C:37]([F:40])([F:39])[F:38])=[O:30])[CH:17]=2)=[O:15])[CH:10]=[CH:11][CH:12]=1>CO>[CH3:1][S:2]([OH:5])(=[O:4])=[O:3].[Cl:6][C:7]1[C:8]([CH3:41])=[C:9]([NH:13][C:14]([C:16]2[C:24]3[N:23]=[C:22]([CH2:25][O:26][CH3:27])[NH:21][C:20]=3[CH:19]=[C:18]([NH:28][C:29]([C:31]3[CH:36]=[CH:35][CH:34]=[CH:33][C:32]=3[C:37]([F:38])([F:39])[F:40])=[O:30])[CH:17]=2)=[O:15])[CH:10]=[CH:11][CH:12]=1参加物
4
実験手順
Methanesulfonic acid (1 Eq) was added to a suspension of N-(3-chloro-2-methylphenyl)-2-(methoxymethyl)-6-({[2-(trifluoromethyl)phenyl]carbonyl}amino)-1H-benzimidazole-4-carboxamide (250 mg) (obtained in Example 11) in MeOH (2 ml). After stirring for 30 minutes at room temperature, MeOH was removed under reduced pressure to obtain the titled compound as white powder.
後処理
- customMeOH was removed under reduced pressure