HCID 67168162、化合物 → 7-Iodo-3-(5-phenyl-4-(trifluoromethyl)isoxazol-3-yl)-4,5-dihydronaphtho[1,2-c]isoxazole

HRID 1506533ノート

反応式

HRID 1506533 の反応式
C1(N2C(C(F)(F)F)=C(C3ON=C4C5C(CCC=34)=CC(C=C)=CC=5)C=N2)C=CC=CC=1.[I:31][C:32]1[CH:33]=[C:34]2[C:39](=[CH:40][CH:41]=1)/[C:38](=[N:42]/[OH:43])/[CH2:37][CH2:36][CH2:35]2.[C:44]1([C:50]2[O:54][N:53]=[C:52]([C:55](OC)=O)[C:51]=2[C:59]([F:62])([F:61])[F:60])[CH:49]=[CH:48][CH:47]=[CH:46][CH:45]=1>>[I:31][C:32]1[CH:33]=[C:34]2[C:39](=[CH:40][CH:41]=1)[C:38]1=[N:42][O:43][C:55]([C:52]3[C:51]([C:59]([F:60])([F:61])[F:62])=[C:50]([C:44]4[CH:49]=[CH:48][CH:47]=[CH:46][CH:45]=4)[O:54][N:53]=3)=[C:37]1[CH2:36][CH2:35]2

参加物

4

反応物 3

HCID 67168162HCID 67168162、化合物HCID 671704203-(1-phenyl-5-(trifluoromethyl)-1H-pyrazol-4-yl)-7-vinyl-4,5-dihydronaphtho[1,2-c]isoxazoleHCID 140592659(NE)-N-(6-iodo-3,4-dihydro-2H-naphthalen-1-ylidene)hydroxylamine

生成物 1

HCID 671714697-Iodo-3-(5-phenyl-4-(trifluoromethyl)isoxazol-3-yl)-4,5-dihydronaphtho[1,2-c]isoxazole

実験手順

The titled compound was prepared using the experimental protocol described for Preparation 89A employing (E)-6-iodo-3,4-dihydronaphthalen-1(2H)-one oxime (121A) and methyl 5-phenyl-4-(trifluoromethyl)isoxazole-3-carboxylate (Intermediate I-5) as starting materials. The compound had an HPLC retention time=4.42 min. (condition C); LC/MS M+1=509.0.

出典と根拠

ORDレコード
ord-8b415f84974f471fa71953461d3b0ef1
出典データセット
uspto-grants-2015_12
特許番号
US09216972B2

反応ノート

読み込み中…