4-Benzyloxy-2(1H)-pyridone → 4-(4-fluorobenzyloxy)-1-(4-hydroxyphenyl)-1H-pyrimidin-2-one

HRID 15066

反応式

HRID 15066 の反応式
C(OC1C=CN([C:15]2[CH:20]=[CH:19][C:18]([O:21]CCN(C)C)=[CH:17][CH:16]=2)C(=O)C=1)C1C=CC=CC=1.C(OC1C=CNC(=O)C=1)C1C=CC=CC=1.[F:43][C:44]1[CH:58]=[CH:57][C:47]([CH2:48][O:49][C:50]2[CH:55]=[CH:54][NH:53][C:52](=[O:56])[N:51]=2)=[CH:46][CH:45]=1>>[F:43][C:44]1[CH:58]=[CH:57][C:47]([CH2:48][O:49][C:50]2[CH:55]=[CH:54][N:53]([C:15]3[CH:20]=[CH:19][C:18]([OH:21])=[CH:17][CH:16]=3)[C:52](=[O:56])[N:51]=2)=[CH:46][CH:45]=1

参加物

4

反応物 3

HCID 36077244-Benzyloxy-2(1H)-pyridoneHCID 115596254-benzyloxy-1-{4-[2-(dimethylamino)ethoxy]phenyl}-1H-pyridin-2-oneHCID 178518416HCID 178518416、化合物

生成物 1

HCID 684303764-(4-fluorobenzyloxy)-1-(4-hydroxyphenyl)-1H-pyrimidin-2-one

実験手順

Steps (3) and (4) of Example 1 were repeated except that 4-benzyloxy-1H-pyridin-2-one which was used in Step (3) of Example 1 was replaced with 4-(4-fluorobenzyloxy)-1H-pyrimidin-2-one, to provide the title compound.

出典と根拠

ORDレコード
ord-e56c0d021ff44232a5d711bf5c79d02b
出典データセット
uspto-grants-2010_06
特許番号
US07732456B2

関連ノート

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