Ammonia chloride → 1-(5-methyl-4-(o-tolyl)-4H-1,2,4-triazol-3-yl)-2-phenylethanone

HRID 1506630ノート

反応式

HRID 1506630 の反応式
[CH3:1][C:2]1[N:3]([C:12]2[CH:17]=[CH:16][CH:15]=[CH:14][C:13]=2[CH3:18])[C:4]([C:7]([O:9]CC)=O)=[N:5][N:6]=1.[CH2:19]([Mg]Cl)[C:20]1[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=1.[Cl-].N>C1(C)C=CC=CC=1>[CH3:1][C:2]1[N:3]([C:12]2[CH:17]=[CH:16][CH:15]=[CH:14][C:13]=2[CH3:18])[C:4]([C:7](=[O:9])[CH2:19][C:20]2[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=2)=[N:5][N:6]=1

参加物

5

反応物 3

HCID 20976574Ammonia chlorideHCID 90281310ethyl 5-methyl-4-(o-tolyl)-4H-1,2,4-triazole-3-carboxylateHCID 178418336HCID 178418336、化合物

生成物 1

HCID 902812771-(5-methyl-4-(o-tolyl)-4H-1,2,4-triazol-3-yl)-2-phenylethanone

試薬・触媒・溶媒 1

HCID 1140Toluene溶媒

実験手順

To a solution of 10C (1.0 g, 4.1 mmol) in toluene cooled by an ice bath, benzylmagnesium chloride (2M in THF) (3.0 mL, 6.0 mmol) was added dropwise. After one hour, ammonia chloride solution was added to the mixture and extracted with ethyl acetate (50 mL twice). The organic layer was dried with Na2SO4, filtered and concentrated and used without further purification. MS (m/z) 292 [M+H]+.

後処理

  1. extractionextracted with ethyl acetate (50 mL twice)
  2. dry with materialThe organic layer was dried with Na2SO4
  3. filtrationfiltered
  4. concentrationconcentrated
  5. customused without further purification

出典と根拠

ORDレコード
ord-117dee3e4ab740fe9abba715ad453a5d
出典データセット
uspto-grants-2015_12
特許番号
US09220710B2

反応ノート

読み込み中…