Benzenesulfonyl chloride → Methyl 2-benzenesulphonylamino-4-methyl-5-phenylthiophene-3-carboxylate

反応式

[C:1]1([S:7](NC2SC3CCCCC=3C=2C(OCC)=O)(=[O:9])=[O:8])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[NH2:25][C:26]1[S:27][C:28]([C:36]2[CH:41]=[CH:40][CH:39]=[CH:38][CH:37]=2)=[C:29]([CH3:35])[C:30]=1[C:31]([O:33][CH3:34])=[O:32].C1(S(Cl)(=O)=O)C=CC=CC=1>>[C:1]1([S:7]([NH:25][C:26]2[S:27][C:28]([C:36]3[CH:41]=[CH:40][CH:39]=[CH:38][CH:37]=3)=[C:29]([CH3:35])[C:30]=2[C:31]([O:33][CH3:34])=[O:32])(=[O:9])=[O:8])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1

参加物

反応物 3

HCID 7369Benzenesulfonyl chloride

HCID 391240Ethyl 2-(benzenesulfonamido)-4,5,6,7-tetrahydrobenzothiophene-3-carboxylate

HCID 921213Methyl 2-amino-4-methyl-5-phenylthiophene-3-carboxylate

生成物 1

HCID 68278826Methyl 2-benzenesulphonylamino-4-methyl-5-phenylthiophene-3-carboxylate

実験手順

Prepared by proceeding in a similar manner to Intermediate 1, starting from methyl 2-amino-4-methyl-5-phenylthiophene-3-carboxylate and benzenesulphonyl chloride

後処理

customPrepared

出典と根拠

ORDレコード: ord-cbad8fd97f7d4cde975281a6474fe372
出典データセット: uspto-grants-2015_12
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US09221787B2

反応ノート

読み込み中…