Potassium Iodide → 1-(3-Hydroxypropyl)-1,2,3-triazole
反応式
[NH:1]1[CH:5]=[CH:4][N:3]=[N:2]1.C(=O)([O-])[O-].[K+].[K+].[I-].[K+].Br[CH2:15][CH2:16][CH2:17][OH:18]>O1CCOCC1>[N:1]1([CH2:15][CH2:16][CH2:17][OH:18])[CH:5]=[CH:4][N:3]=[N:2]1参加物
6
反応条件
- 温度
- 100 °C
実験手順
1,2,3-triazole (2 g, 28.96 mmol) was dissolved in 1,4-dioxane (40 mL), and potassium carbonate (8 g, 57.92 mmol), potassium iodide (962 mg, 5.79 mmol) and 3-bromopropanol (3.3 mL, 43.43 mmol) were added thereto, followed by stirring at 100° C. for 3 hours. After the reaction was completed, the reactants were cooled to room temperature and filtered. The filtrate was concentrated under reduced pressure. The resulting residue was purified by column chromatography to afford the title compound (2.5 g, 68%).
後処理
- temperaturethe reactants were cooled to room temperature
- filtrationfiltered
- concentrationThe filtrate was concentrated under reduced pressure
- customThe resulting residue was purified by column chromatography
出典と根拠
- ORDレコード
- ord-f53fdde1f1b443b6830e572b0b326059
- 出典データセット
- uspto-grants-2015_12
- 特許番号
- US09221790B2
反応ノート
読み込み中…