Hydrochloric Acid → HCID 54575276、化合物
反応式
[N:1]1([CH2:6][CH2:7][CH2:8][N:9]2[CH2:14][CH2:13][CH:12]([CH2:15][NH:16][C:17](=[O:28])[C:18]3[CH:23]=[C:22]([Cl:24])[C:21]([NH2:25])=[CH:20][C:19]=3[O:26][CH3:27])[CH2:11][CH2:10]2)[CH:5]=[N:4][N:3]=[N:2]1.Cl>C(O)C>[ClH:24].[N:1]1([CH2:6][CH2:7][CH2:8][N:9]2[CH2:10][CH2:11][CH:12]([CH2:15][NH:16][C:17](=[O:28])[C:18]3[CH:23]=[C:22]([Cl:24])[C:21]([NH2:25])=[CH:20][C:19]=3[O:26][CH3:27])[CH2:13][CH2:14]2)[CH:5]=[N:4][N:3]=[N:2]1参加物
4
実験手順
N-((1-(3-(tetrazol-1-yl)propyl)piperidin-4-yl)methyl)-4-amino-5-chloro-2-methoxybenzamide (Example 2) (517 mg, 1.27 mmol) was dissolved in ethanol (10 mL) and a 12N hydrochloride solution (0.16 mL, 1.90 mmol) was added thereto. The reaction mixture was stirred at room temperature for 12 hours and then filtered to afford the title compound (417 mg, 74%).