Ethyl 2-formylpyridine-4-carboxylate → HCID 90375097、化合物
反応式
[CH:1]([C:3]1[CH:8]=[C:7]([C:9]([O:11][CH2:12][CH3:13])=[O:10])[CH:6]=[CH:5][N:4]=1)=O.Cl.[CH3:15][N:16]([CH3:21])[C:17](=[O:20])[CH2:18][NH2:19]>C(N(CC)CC)C>[CH3:15][N:16]([CH3:21])[C:17]([CH2:18][NH:19][CH2:1][C:3]1[CH:8]=[C:7]([C:9]([O:11][CH2:12][CH3:13])=[O:10])[CH:6]=[CH:5][N:4]=1)=[O:20]参加物
4
実験手順
By General Procedure A from Ethyl 2-formylpyridine-4-carboxylate, N,N-dimethylglycineamide hydrochloride, and triethylamine. Purification by column chromatography with a gradient of 0-10% MeOH in DCM gave the title product as yellow oil. 1H NMR (300 MHz, chloroform-d): δ ppm 8.69 (s, 1H), 7.94 (s, 1H), 7.72 (d, 1H), 4.40 (q, 2H), 4.03 (s, 2H), 3.48 (s, 2H), 2.95 (d, 6H), 1.40 (t, 3H).
後処理
- customPurification by column chromatography with a gradient of 0-10% MeOH in DCM
出典と根拠
- ORDレコード
- ord-bdf493bce85e4bf5aab0eef62da8dbb2
- 出典データセット
- uspto-grants-2015_12
- 特許番号
- US09221801B2
反応ノート
読み込み中…