2-amino-N,N-dimethylacetamide hydrochloride → HCID 90375186、化合物
反応式
Cl.[CH3:2][N:3]([CH3:8])[C:4](=[O:7])[CH2:5][NH2:6].[Si:9]([O:16][CH2:17][C:18]1[CH:23]=[CH:22][N:21]=[C:20]([CH:24]=O)[CH:19]=1)([C:12]([CH3:15])([CH3:14])[CH3:13])([CH3:11])[CH3:10]>C(N(CC)CC)C>[Si:9]([O:16][CH2:17][C:18]1[CH:23]=[CH:22][N:21]=[C:20]([CH2:24][NH:6][CH2:5][C:4]([N:3]([CH3:8])[CH3:2])=[O:7])[CH:19]=1)([C:12]([CH3:15])([CH3:14])[CH3:13])([CH3:10])[CH3:11]参加物
4
実験手順
By General Procedure A from N,N-dimethylglycineamide hydrochloride, triethylamine, and 4-{[(tert-butyldimethylsilyl)oxy]methyl}pyridine-2-carbaldehyde. Purification by column chromatography (0-10% MeOH in DCM) gave the title product as yellow oil. 1H NMR (300 MHz, chloroform-d): δ ppm 8.49 (d, 1H), 7.32 (s, 1H), 7.17 (d, 1H), 4.74 (s, 2H), 3.97 (s, 2H), 3.47 (s, 2H), 2.95 (d, 6H), 0.95 (s, 9H), 0.11 (s, 6H).