4-Dimethylaminobutylamine → HCID 90374984、化合物
反応式
[Si:1]([O:8][CH2:9][C:10]1[CH:15]=[CH:14][N:13]=[C:12]([CH:16]=O)[CH:11]=1)([C:4]([CH3:7])([CH3:6])[CH3:5])([CH3:3])[CH3:2].[NH2:18][CH2:19][CH2:20][CH2:21][CH2:22][N:23]([CH3:25])[CH3:24]>>[Si:1]([O:8][CH2:9][C:10]1[CH:15]=[CH:14][N:13]=[C:12]([CH2:16][NH:18][CH2:19][CH2:20][CH2:21][CH2:22][N:23]([CH3:25])[CH3:24])[CH:11]=1)([C:4]([CH3:7])([CH3:6])[CH3:5])([CH3:3])[CH3:2]参加物
3
実験手順
By General Procedure A from 4-{[(tert-butyldimethylsilyl)oxy]methyl}pyridine-2-carbaldehyde and (4-aminobutyl)dimethylamine. Purification by column chromatography (DCM/MeOH (95:5)) gave the title compound as greenish oil. 1H-NMR (300 MHz, CDCl3): δ 8.48 (d, 1H), 7.25 (s, 2H), 7.10 (d, 1H), 4.70 (s, 2H), 3.90 (s, 2H), 2.60 (m, 2H), 2.30 (m, 2H), 2.20 (s, 6H), 1.50 (m, 4H), 1.00 (s, 9H, 0.9 (s, 9H), 0.1 (s, 6H) ppm.
後処理
- customPurification by column chromatography (DCM/MeOH (95:5))
出典と根拠
- ORDレコード
- ord-de5cdcfe71e249898b47fab3b0703b9b
- 出典データセット
- uspto-grants-2015_12
- DOI