5-Bromo-2-(2-phenylacetamido)benzoate → 6-Bromo-3-(2-chlorophenyl)-4-hydroxyquinolin-2(1H)-one

HRID 1507288ノート

反応式

HRID 1507288 の反応式
[Br:1][C:2]1[CH:3]=[CH:4][C:5]([NH:12][C:13](=[O:22])[CH2:14][C:15]2[CH:20]=[CH:19][CH:18]=[CH:17][C:16]=2[Cl:21])=[C:6]([CH:11]=1)[C:7]([O:9]C)=O.BrC1C=CC(NC(=O)CC2C=CC=CC=2)=C(C=1)C([O-])=O.BrC1C=C2C(=CC=1)NC(=O)C(C1C=CC=CC=1)=C2O>>[Br:1][C:2]1[CH:11]=[C:6]2[C:5](=[CH:4][CH:3]=1)[NH:12][C:13](=[O:22])[C:14]([C:15]1[CH:20]=[CH:19][CH:18]=[CH:17][C:16]=1[Cl:21])=[C:7]2[OH:9]

参加物

4

反応物 3

HCID 405484265-Bromo-2-(2-phenylacetamido)benzoateHCID 867160566-Bromo-4-hydroxy-3-phenylquinolin-2(1H)-oneHCID 86716059Methyl 5-bromo-2-(2-(2-chlorophenyl)acetamido)benzoate

生成物 1

HCID 867160586-Bromo-3-(2-chlorophenyl)-4-hydroxyquinolin-2(1H)-one

実験手順

The title compound was prepared using methyl 5-bromo-2-(2-(2-chlorophenyl)acetamido)benzoate (Intermediate 2: step a) in place of 5-bromo-2-(2-phenylacetamido)benzoate using the procedure described for Intermediate 1: step b.

出典と根拠

ORDレコード
ord-2a8690e2907941f4b67707c39cb06fcb
出典データセット
uspto-grants-2015_12
特許番号
US09221804B2

反応ノート

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