Hydrochloric Acid → HCID 178517540、化合物

HRID 1507504

反応式

HRID 1507504 の反応式
[S:1]1[C:5]2[CH:6]=[CH:7][CH:8]=[CH:9][C:4]=2[N:3]=[C:2]1[C:10]1[C:11]([Cl:30])=[N:12][C:13]([CH:17]2[CH2:22][CH2:21][N:20](C(OC(C)(C)C)=O)[CH2:19][CH2:18]2)=[N:14][C:15]=1[OH:16].Cl>CO>[S:1]1[C:5]2[CH:6]=[CH:7][CH:8]=[CH:9][C:4]=2[N:3]=[C:2]1[C:10]1[C:15]([OH:16])=[N:14][C:13]([CH:17]2[CH2:18][CH2:19][NH:20][CH2:21][CH2:22]2)=[N:12][C:11]=1[Cl:30]

参加物

4

反応物 2

HCID 313Hydrochloric AcidHCID 178451808HCID 178451808、化合物

生成物 1

HCID 178517540HCID 178517540、化合物収率 98%

試薬・触媒・溶媒 1

HCID 887Methanol溶媒

実験手順

Into a solution of tert-butyl 4-[5-(1,3-benzothiazol-2-yl)-4-chloro-6-hydroxypyrimidin-2-yl]piperidine-1-carboxylate (44.7 g, 100.01 mmol, 1.00 equiv) in methanol (50 ml) was added concentrated hydrochloric acid (50 mL, 12 M). The resulting solution was stirred for 30 min at room temperature. Concentration under vacuum gave 34 g of 5-(1,3-benzothiazol-2-yl)-6-chloro-2-(piperidin-4-yl)pyrimidin-4-ol as a yellow solid, which was used directly for next step without further purification. MS m/z [M+H](ESI): 347.

後処理

  1. concentrationConcentration under vacuum

出典と根拠

ORDレコード
ord-bd1135f847474bb9bc2305e9ca91e855
出典データセット
uspto-grants-2015_12
特許番号
US09221809B2

関連ノート

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